• 姓       名:陈建
  • 职       称:副教授
  • 学       位:博士
  • 所在机构:湖南科技大学 化学化工学院
  • 出生年月: 1980年07月
  • 籍       贯:湖南省沅江市
  • 研究方向:新型荧光功能性高分子纳米材料的设计合成与应用;共轭聚合物荧光纳米材料的设计合成;新型细乳液聚合技术
个人简介 学术成果 发表论文

教育背景

2005年硕士毕业于湘潭大学高分子化学与物理专业,师从张海良教授从事利用活性聚合方法合成功能性嵌段共聚物及其性能研究。

2009年6月博士毕业于华南理工大学材料学专业,师从曾钫教授和吴水珠教授从事基于聚合物纳米粒子体系的荧光共振能量转移研究。

工作经历

湖南科技大学教育部重点实验室专职科研人员。

学术兼职

中国化学会会员、湖南省化学化工学会会员。

近年来,先后共主持各类科研项目10来项,其中包括国家自然科学基金课题3项,教育部留学回国人员启动基金课题1项,省自然科学基金课题1项,省教育厅优秀青年项目1项、中国博士后基金课题2项等。

在《Small》、《Chem. Eur. J.》、《Macromolecules》、《Chem. Commun.》、《Polym. Chem.》等国内外杂志上发表SCI论文30余篇,引用500余次。

申请发明专利15项,授权10项。

科研项目

[1]国家自然科学基金面上项目:具有基因载体功能的光开关近红外荧光聚合物纳米材料设计合成与生物成像研究(No. 51773056),2018-2021;

[2]国家自然科学基金面上项目:水分散性荧光聚合物量子点设计合成及多色可调光开关研究(No. 51373002),2014-2017;

[3]国家自然科学基金青年项目:新型两亲性多色荧光聚合物纳米粒子的设计合成及FRET研究(No. 51003026),2011-2013;

[4]中国博士后科学基金特别资助项目:荧光聚合物量子点构建与硫离子比率荧光检测及成像研究(No. 2015T80867), 2015-2016;

[5]中国博士后科学基金项目:新型荧光聚合物量子点制备与汞离子荧光比率检测应用(第55批面上一等资助,No. 2014M550418),2014-2015;

[6]教育部留学回国人员科研启动基金:基于共轭聚合物的光开关荧光纳米材料设计及FRET研究, 2014-2016;

[7]湖南省教育厅优秀青年基金:新型两亲性光开关荧光聚合物纳米粒子设计合成与优化,(No. 12B041),2012-2014;

[8]湖南省自然科学基金青年项目:聚合物纳米粒子中荧光共振能量转移体系的构建与优化(No. 11JJ4016),2011-2013。

论文专著

[1]. Peisheng Zhang, Hong Wang, Di Zhang, Xuyao Zeng, Rongjin Zeng,* Lehui Xiao*, Hongwen Tao Yunfei Long, Pinggui Yi, and Jian Chen*. Two-photon fluorescent probe for lysosome-targetable hypochlorous acid detection within living cells. Sensors and Actuators B 2017, DOI: 10.1016/j.snb.2017.09.025

[2]. Hong Wang, Peisheng Zhang,* Yongxiang Hong, Bin Zhao, Pinggui Yi and Jian Chen*. Ratiometric imaging of lysosomal hypochlorous acid enabled by FRET-based polymer dots. Polymer Chemistry 2017, 8: 5795–5802.

[3]. Peisheng Zhang*, Hong Wang, Yongxiang Hong, Maolin Yu, Rongjin Zeng, Yunfei Long, Jian Chen*. Selective visualization of endogenous hypochlorous acid in zebrafish during lipopolysaccharide-induced acute liver injury using a polymer micelles-based ratiometric fluorescent probe. Biosensors and Bioelectronics 2018, 99: 318–324.

[4]. Weibang Zhong1, Xuyao Zeng1, Jian Chen*, Yongxiang Hong, Lehui Xiao and Peisheng Zhang*. Photoswitchable fluorescent polymeric nanoparticles for rewritable fluorescence patterning and intracellular dual-color imaging with AIE-based fluorogens as FRET donors. Polymer Chemistry 2017, 8: 4849-4855.

[5]. Jian Chen*, Chonghua Zhang, Kun Lv, Hong Wang, Peisheng Zhang*, Pinggui Yi, Jianhui Jiang*. A silica nanoparticle-based dual-responsive ratiometric probe for visualizing hypochlorite and temperature with distinct fluorescence signals. Sensors and Actuators B 2017, 251: 533-541.

[6]. Jian Chen, Adam W. Ziegler, Baoming Zhao, Wei Wan and Alexander D. Q. Li*. Chemomechanical-force-induced folding–unfolding directly controls distinct fluorescence dual-color switching. Chemical Communications, 2017, 53, 4993-4996.

[7]. Hong Wang1, Peisheng Zhang1, Jian Chen*, Ya Li, Maolin Yu, Yunfei Long, Pinggui Yi. Polymer nanoparticle-based ratiometric fluorescent probe for imaging Hg2+ ions in living cells. Sensors and Actuators B 2017, 242: 818-824.

[8]. Kun Lv, Jian Chen*, Hong Wang, Peisheng Zhang*, Maolin Yu, Yunfei Long, Pinggui Yi. One-pot fabrication of FRET-based fluorescent probe for detecting copper ion and sulfide anion in 100% aqueous media. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2017, 177, 63-68.

[9]. Hong Wang, Jian Chen*, Yongxiang Hong, Kun Lv, Maolin Yu, Peisheng Zhang*, Yunfei Long, and Pinggui Yi. Fabrication of Water-soluble Fluorescent Polymeric Micelles for Selective Detection of Hg2+ in Blood Serum. Analytical Sciences 2017, 33, 591-597.

[10]. Jian Chen*, Ying Tang, Hong Wang, Peisheng Zhang*, Ya Li and Jianhui Jiang. Design and fabrication of fluorescence resonance energy transfer-mediated fluorescent polymer nanoparticles for ratiometric sensing of lysosomal pH, Journal of Colloid and Interface Science 2016, 484: 298-307.

[11]. Jian Chen*, Ya Li, Kun lv, Weibang Zhong, Hong Wang, Zhan Wu*, Pinggui Yi* and Jianhui Jiang. Cyclam-Functionalized Carbon Dots Sensor for Sensitive and Selective Detection of Copper(II) Ion and sulfide anion in Aqueous Media and Its Imaging in Live Cells. Sensors and Actuators B 2016, 224: 298-306.

[12]. Jian Chen,* Ya Li, Weibang Zhong, Hong Wang, Peisheng Zhang* and Jianhui Jiang. A highly selective fluorescent and colorimetric chemosensor for Hg2+ based on a new rhodamine derivative. Analytical Methods 2016, 8: 1964-1967.

[13]. Jian Chen,* Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi,* Jianhui Jiang*. Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging. Macromolecules 2015, 48: 3500-3508.

[14]. Jian Chen*, Ya Li, Weibang Zhong, Qingyang Hou, Hong Wang, Xiang Sun and Pinggui Yi. Novel fluorescent polymeric nanoparticles for highly selective recognition of copper ion and sulfide anion in water. Sensors and Actuators B 2015, 206: 230-238.

[15]. Jian Chen*, Fuhua Huang, Hong Wang, Ya Li, Shengli Liu, Pinggui Yi. One-pot preparation of multicolor polymeric nanoparticles with high brightness by single wavelength excitation. Journal of Applied Polymer Science 2015, 132: 41492.

[16]. Bo Liao*, Peng Long, Benqiao He*, Shoujun Yi, Baoli Ou, Shaohua Shen, Jian Chen*. Reversible Fluorescence Modulation of Spiropyrans-functionalized Carbon Nanoparticles. Journal of Materials Chemistry C 2013, 1: 3716-3721.

[17]. Peisheng Zhang, Jian Chen*, Fuhua Huang, Zhiqiang Zeng, Jia Hu, Pinggui Yi*, Fang Zeng and Shuizhu Wu. One-pot fabrication of polymer nanoparticle-based chemosensor for Cu2+ detection in aqueous media. Polymer Chemistry 2013, 4: 2325-2332.

[18]. Jian Chen*, Dapeng Wang, Andrey Turshatov, Rafael Muñoz-Espí, Ulrich Ziener,* Kaloian Koynov, Katharina Landfester*. One-pot Fabrication of Amphiphilic Photoswitchable Thiophene-Based Fluorescent Polymer Dots. Polymer Chemistry 2013, 4: 773-781.

[19]. Jian Chen, Jie Shu, Simone Schobloch, Anja Kroeger, Robert Graf, Rafael Muñoz-Espí, Katharina Landfester, and Ulrich Ziener*. A New Design Strategy for the Synthesis of Unsubstituted Polythiophene with Defined High Molecular Weight. Macromolecules 2012, 45: 5108-5113.

[20]. Jian Chen*, Peisheng Zhang, Gang Fang, Chao Weng, Jia Hu, Pinggui Yi*, Xianyong Yu and Xiaofang Li. One-pot synthesis of amphiphilic reversible photoswitchable fluorescent nanoparticles and their fluorescence modulation properties. Polymer Chemistry 2012, 3: 685-693.

[21]. Jian Chen*, Peisheng Zhang, Gang Fang, Pinggui Yi*, Fang Zeng and Shuizhu Wu. Design and Synthesis of FRET-Mediated Multicolor and Photoswitchable Fluorescent Polymer Nanoparticles with Tunable Emission Properties. Journal of Physical Chemistry B 2012, 116(14):4354-4362.

[22]. Jian Chen, Peisheng Zhang, Gang Fang, Pinggui Yi*, Xianyong Yu, Xiaofang Li, Fang Zeng* and Shuizhu Wu. Synthesis and Characterization of Novel Reversible Photoswitchable Fluorescent Polymeric Nanoparticles via One-Step Miniemulsion Polymerization. Journal of Physical Chemistry B 2011, 115(13): 3354-3362.

[23]. Bo Liao*, Jian Chen, Haowen Huang, Xiaofang Li and Benqiao He*. Gold nanocluster-based light-controlled fluorescence molecular switch. Journal of Materials Chemistry 2011, 21(16): 5867-5869.

[24]. Jian Chen, Peisheng Zhang, Xianyong Yu, Xiaofang Li, Hongwen Tao and Pinggui Yi*. Fabrication of Novel Polymer Nanoparticle-Based Fluorescence Resonance Energy Transfer Systems and their Tunable Fluorescence Properties. Journal of Macromolecular Science Part A 2011. 48(3): 219-226.

[25]. Jian Chen, Peisheng Zhang, Xianyong Yu, Xiaofang Li, Hongwen Tao and Pinggui Yi*. Fabrication of Novel Reversible Photoswitchable Fluorescent Nanoparticles. Journal of Macromolecular Science Part A 2011. 48(8): 637-643.

[26]. Jian Chen, Peisheng Zhang and Pinggui Yi*. Preparation of Fluorescence Tunable Polymer Nanoparticles by One-step Mini-emulsion. Journal of Macromolecular Science Part A 2010. 47(11): 1135-1141.

[27]. Jian Chen, Fang Zeng and Shuizhu Wu*. Construction of Energy Transfer Systems within Nanosized Polymer Micelles and their Fluorescence Modulation Properties. Chemphyschem 2010, 11(5): 1036-1043.

[28]. Jian Chen, Fang Zeng, Shuizhu Wu*, Junhua Su and Zhen Tong. Photoreversible Fluorescent Modulation of Nanoparticles via One-Step Miniemulsion Polymerization. Small 2009, 5(8): 970-978.

[29]. Jian Chen, Fang Zeng*, Shuizhu Wu*, Junhua Su, Jianqing Zhao and Zhen Tong. A facile approach for cupric ion detection in aqueous media using polyethyleneimine/PMMA core-shell fluorescent nanoparticles. Nanotechnology 2009, 20(36): 365502.

[30]. Jian Chen, Fang Zeng, Shuizhu Wu*, Qiming Chen and Zhen Tong. A core-shell nanoparticle approach to photoreversible fluorescence modulation of a hydrophobic dye in aqueous media. Chemistry-a European Journal 2008, 14(16): 4851-4860.

[31]. Jian Chen, Fang Zeng*, Shuizhu Wu*, Jianqing Zhao, Qiming Chen and Zhen Tong. Reversible fluorescence modulation through energy transfer with ABC triblock copolymer micelles as scaffolds. Chemical Communications 2008, (43): 5580-5582.

专利成果

[1]. 陈建, 李亚, 黄富华, 孙祥, 王宏, 一种具有铜离子和硫阴离子双识别功能的水分散性荧光聚合物纳米粒子及其制备方法和应用, 发明专利, 授权专利号: ZL201310322589.2。

[2]. 陈建, 钟维邦, 孙祥, 李亚, 候庆扬, 易平贵, 一种检测汞离子的两亲性聚合物纳米粒子、制备方法及应用, 发明专利, 授权专利号: ZL201410061992.9。

[3]. 陈建, 钟维邦, 李亚, 吕锟, 李明莉, 廖博, 易平贵, 一种两亲性光开关荧光聚合物纳米粒子及其制备方法, 发明专利, 授权专利号: ZL201410352430.X。

[4]. 陈建, 王宏, 李亚, 侯庆杨, 吕锟, 吉添, 李明莉, 周智华, 易平贵,一种具有pH值和汞离子比率检测功能的水分散性荧光聚合物纳米粒子、制备方法及应用, 发明专利, 授权专利号: ZL201410369075.7。

[5]. 陈建, 李亚, 钟维邦, 吕锟, 王宏, 廖博, 易平贵, 一种具有铜离子和半胱氨酸双识别功能的碳量子点传感器及其制备方法和应用, 发明专利, 授权专利号: ZL201410610062.4。

[6]. 陈建, 李亚, 王宏, 钟维邦, 吕锟, 侯庆阳, 易平贵, 一种具有硫离子、铜离子和pH值多重检测功能的荧光传感器制备方法及应用, 发明专利, 授权专利号: ZL201510001105.3。

[7]. 陈建, 钟维邦, 李亚, 吕锟, 王宏, 廖博, 易平贵, 两亲性多色光开关荧光聚合物纳米粒子及其制备方法, 发明专利, 授权专利号: ZL201410776223.7。

[8]. 陈建, 李亚, 钟维邦, 吕锟, 王宏, 侯庆阳, 易平贵, 基于罗丹明衍生物的比色汞离子传感器的制备方法及应用, 发明专利, 授权专利号: ZL201410776232.6。

[9]. 陈建、李亚、王宏、钟维邦、吕锟、洪永想、易平贵,一种基于聚乙二醇的硫离子传感器及其制备方法和应用,发明专利, 授权专利号: ZL201510413193.8。

[10]. 陈建、吕锟、洪永想、钟维邦、王宏、易平贵,一种具有多识别功能的荧光聚合物及其制备方法和应用,发明专利, 授权专利号: ZL201510425158.8。

奖励/荣誉

2010年获广东省优秀博士学位论文;

2011年获全国优秀博士学位论文提名奖;

2014年获湖南省化学化工学会第十三届青年化学化工奖。